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Trends in Immunology

Astrocyte interleukin-3 preps microglia

October 14, 2021

Brain β-amyloid (Aβ) deposition is a biomarker for Alzheimer’s disease (AD) and other dementias, in which Aβ amounts correlate with disease burden. McAlpine et al. reveal that astrocyte...

Clash of the titans: interferons and SARS-CoV-2

October 15, 2021

Interferons are our first line of defense against invading viruses. However, viruses encode effector proteins that can modulate human interferon responses. In this forum article, we highlight...

Ragulator-Rag and ROS TORment gasdermin D pore formation

October 15, 2021

Upon cleavage, the Gasdermin D (GSDMD) N-terminal fragment assembles into pores on the plasma membrane to orchestrate the lytic cell death known as pyroptosis. In a recent article, Evavold et al....

Staggered starts in the race to T cell activation

October 11, 2021

How T lymphocytes tune their responses to different strengths of stimulation is a fundamental question in immunology. Recent work using new optogenetic, single-cell genomic, and live-imaging...

The meningeal lymphatics: regulators of Aβ immunotherapy?

October 13, 2021

A new study by Da Mesquita et al. reports on how meningeal lymphatic modulation may influence amyloid-beta immunotherapy and microglial function in mouse models of Alzheimer’s disease (AD). This...

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