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Trends in Immunology

A new perspective on mesenchymal–immune interactions in adipose tissue

April 10, 2021

The mammalian immune system has crucial homeostatic functions in different adipose depots. However, white adipose tissue (WAT) inflammation is a hallmark of obesity and can contribute to type 2...

Deregulation of enhancer structure, function, and dynamics in acute lymphoblastic leukemia

April 12, 2021

Enhancers control dynamic changes in gene expression and orchestrate the tightly controlled transcriptional circuitries that direct and coordinate cell growth, proliferation, survival, lineage...

Enemy or ally? Fasting as an essential regulator of immune responses

April 14, 2021

Nutrition is essential for supplying an organism with sufficient energy to maintain its bodily functions. Apart from serving as an energy supply, the immunomodulatory effects of diet are emerging as a...

RNA decay machinery safeguards immune cell development and immunological responses

April 12, 2021

mRNA decay systems control mRNA abundance by counterbalancing transcription. Several recent studies show that mRNA decay pathways are crucial to conventional T and B cell development in vertebrates,...

Synovial macrophages: from ordinary eaters to extraordinary multitaskers

April 6, 2021

Like other tissues, joints contain resident macrophages, and their diversity is only beginning to be characterized. Based on the highlights of recent studies, we discuss where current challenges lie...

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