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Trends in Immunology

Immunomodulatory impact of α-fetoprotein

May 9, 2022

α-Fetoprotein (AFP) is a fetal glycoprotein produced by most human hepatocellular carcinoma tumors. Research has focused on its immunosuppressive properties in pregnancy, autoimmunity, and cancer,...

Inflammatory comorbidities: to train or not to train?

May 8, 2022

Inflammatory stimuli reprogram innate immune cells to generate rigorous responses to future challenge with heterologous stimuli through trained immunity. Li et al. show that training of hematopoietic...

Insights into how SARS-CoV2 infection induces cytokine storms

May 7, 2022

Severe coronavirus disease 2019 (COVID-19) has been associated with cytokine storms and hyperinflammation. In a recent study, Junqueira et al. provide evidence that antibody-mediated uptake of severe...

The extracellular matrix and immunity: breaking the old barrier in cancer

May 5, 2022

Extracellular matrix (ECM) is an integral component of solid cancers; however, the impact of the ECM on antitumor immunity has remained elusive. Sun and colleagues now demonstrate that discoidin...

Zebrafish: an underutilized tool for discovery in host–microbe interactions

May 5, 2022

Zebrafish are relatively new to the field of host–pathogen interactions, although they have been a valuable vertebrate model for decades in developmental biology and neuroscience. Transparent...

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