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Trends in Immunology

Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology

March 11, 2023

Some of the current and former organizers of the Cold Spring Harbor Laboratory (CSHL) ‘Gene Expression and Signaling in the Immune System’ (GESIS) meeting offer opinions on emerging questions in...

Exhausted CD8+ T cells face a developmental fork in the road

March 11, 2023

CD8+ T cells play a crucial role in eliminating virus-infected cells and tumors. Armed with potent cytolytic potential and an inherent capacity to produce proinflammatory cytokines, CD8+ T cells are...

Genetic conflicts and the origin of self/nonself-discrimination in the vertebrate immune system

March 18, 2023

All forms of life are prone to attack by genetic parasites. To defend themselves against these invaders, host cells and organisms have evolved myriad self/nonself recognition systems. It appears that...

Programming cytomegalovirus as an HIV vaccine

March 7, 2023

Over the past 40 years of HIV-1/HIV vaccine development research, two key points have become abundantly clear. First, adaptive immune vulnerabilities of HIV and its simian counterpart SIV are few and...

p53 regulates the mitochondrial immune checkpoint

March 16, 2023

Mitochondrial outer membrane permeabilization (MOMP) is crucial for the cytosolic accumulation of mitochondrial DNA (mtDNA) species that are required to jumpstart innate and adaptive immunity. Recent...

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