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Trends in Immunology

A variegated model of transcription factor function in the immune system

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Cells of the immune system must mount diverse and highly specialized responses to foreign antigens, inflammatory triggers, and deviations from organ homeostasis. These responses are mediated by...

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Thymic selection in mammals is an important step in the generation of mature T cells that can protect us against foreign pathogens while avoiding autoimmunity. Negative selection (see Glossary) is...

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