Borna Mehrad

Borna Mehrad, M.D.

Chief and Professor

Department: MD-PULMONARY MEDICINE
Business Phone: (352) 273-8735
Business Email: emma.dyer@medicine.ufl.edu

About Borna Mehrad

I have been captivated by how the body works since childhood and distinctly remember playing with anatomy models while my schoolmates played with toy trains and cars. I attended medical school at the University of Nottingham in the United Kingdom and went on to complete an internal medicine residency at the University of Texas Southwestern Medical Center. I then trained in infectious diseases at UT Southwestern and did a second fellowship in pulmonary and critical care medicine at the University of Michigan.

Since 1999, I have practiced as a board-certified pulmonary and critical care physician. My clinical area of expertise is lung disease and ICU medicine, and I particularly focus on interstitial lung diseases and sarcoidosis — a group of uncommon and complex illnesses that result in inflammation and scarring of the lungs.

In addition to seeing patients, I have a research laboratory, where my colleagues and I study mechanisms of lung injury and fibrosis. I find the combination of seeing patients and studying their illnesses in the lab deeply fulfilling. My practice of medicine is informed by the underlying science, and my work as a scientist is motivated by the patients I care for.

I serve as the chief of the University of Florida Division of Pulmonary, Critical Care & Sleep Medicine. Our goal as a division is to deliver outstanding medical care to our patients via specialized clinical programs, perform cutting-edge research by fostering collaboration between clinicians and investigators, and to train the next generation of doctors and scientists in our discipline.

I have published many research papers and hold two patents. My laboratory has been continuously funded by the National Institutes of Health. I am a member of the American Society of Clinical Investigators, an honor society for physician-scientists. Among my proudest achievements are the well young doctors and investigators that I have trained who have gone on to successful careers as clinicians and scientists.

Outside work, I enjoy long-distance running and cooking.

Related Links:

Accomplishments

Attending of The Year
2016 · University of Virginia
Americas Top Doctors in Pulmonary Disease
2015-2020 · Americas Top Doctors, Castle Connolly
Fellow
2015 · American College of Chest Physicians
Department of Medicine Research Award
2013 · University of Virginia
Inductee
2013 · American Society of Clinical Investigation

Teaching Profile

Courses Taught
2018
GMS7979 Advanced Research
2021
PHC6722 Environmental and Global Health Research Methods Rotation

Board Certifications

  • Critical Care Medicine
    ABIM
  • Pulmonary Medicine
    ABIM

Clinical Profile

Specialties
  • Pulmonary Disease and Critical Care Medicine

Research Profile

Regulation of lung inflammation and antimicrobial immunity.

Publications

Academic Articles
2025
Cryopreservation of human lung tissue for 3D ex vivo analysis.
Respiratory research. 26(1) [DOI] 10.1186/s12931-025-03265-y. [PMID] 40375251.
2025
Essential role of hepcidin in host resistance to disseminated candidiasis.
Cell reports. 44(5) [DOI] 10.1016/j.celrep.2025.115649. [PMID] 40333187.
2025
Multimodality Imaging for the Diagnosis and Evaluation of Pulmonary Sarcoidosis
Radiology: Cardiothoracic Imaging. 7(2) [DOI] 10.1148/ryct.240294. [PMID] 40047549.
2025
Optimal control of agent-based models via surrogate modeling
PLOS Computational Biology. 21(1) [DOI] 10.1371/journal.pcbi.1012138. [PMID] 39808665.
2025
The evolving role of MRI in pulmonary sarcoidosis: Comparative analysis with PFTs and progression markers.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. 42(1) [DOI] 10.36141/svdld.v42i1.15304. [PMID] 40100106.
2025
The heme scavenger hemopexin protects against lung injury during aspergillosis by mitigating release of neutrophil extracellular traps
JCI Insight. 10(10) [DOI] 10.1172/jci.insight.189151. [PMID] 40232861.
2024
3D Culture Analysis of Cancer Cell Adherence to Ex Vivo Lung Microexplants.
Tissue engineering. Part C, Methods. 30(8):343-352 [DOI] 10.1089/ten.TEC.2024.0146. [PMID] 39078332.
2024
Circulating fibrocyte levels correlate with left ventricular mass in middle-aged healthy adults without hypertension.
American heart journal plus : cardiology research and practice. 45 [DOI] 10.1016/j.ahjo.2024.100442. [PMID] 39238653.
2024
Digital twins in medicine
Nature Computational Science. 4(3):184-191 [DOI] 10.1038/s43588-024-00607-6. [PMID] 38532133.
2024
Essential role of Hepcidin in host resistance to disseminated candidiasis.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2024.10.29.620511. [PMID] 39553949.
2024
Extracellular Vesicle-Associated Neutrophil Elastase Activates Hepatic Stellate Cells and Promotes Liver Fibrogenesis via ERK1/2 Pathway.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2024.08.20.608832. [PMID] 39229038.
2024
Forum on immune digital twins: a meeting report.
NPJ systems biology and applications. 10(1) [DOI] 10.1038/s41540-024-00345-5. [PMID] 38365857.
2024
Personalizing computational models to construct medical digital twins.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2024.05.31.596692. [PMID] 39574674.
2024
Surrogate modeling and control of medical digital twins.
ArXiv. [PMID] 38827450.
2024
Toward mechanistic medical digital twins: some use cases in immunology.
Frontiers in digital health. 6 [DOI] 10.3389/fdgth.2024.1349595. [PMID] 38515550.
2024
Toxicity of microplastic fibers containing azobenzene disperse dyes to human lung epithelial cells cultured at an air-liquid interface
Journal of Hazardous Materials. 480 [DOI] 10.1016/j.jhazmat.2024.136280. [PMID] 39515142.
2023
A Chest Pain Conundrum: Dapsone-Induced Methemoglobinemia in a Heart Transplant Patient.
Cureus. 15(10) [DOI] 10.7759/cureus.46690. [PMID] 37942387.
2023
COVID-19-associated pulmonary aspergillosis in immunocompetent patients: a virtual patient cohort study.
Journal of mathematical biology. 87(1) [DOI] 10.1007/s00285-023-01940-6. [PMID] 37306747.
2023
COVID-19-associated pulmonary aspergillosis in immunocompetent patients: A virtual patient cohort study.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2022.07.18.500514. [PMID] 35898340.
2023
Diagnostic and therapeutic practices of cardiac sarcoidosis in the United States: a nationwide questionnaire based study.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. 40(3) [DOI] 10.36141/svdld.v40i3.14218. [PMID] 37712372.
2023
Hyperpolarized Xenon-129: A New Tool to Assess Pulmonary Physiology in Patients with Pulmonary Fibrosis.
Biomedicines. 11(6) [DOI] 10.3390/biomedicines11061533. [PMID] 37371626.
2023
Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis.
Clinical immunology (Orlando, Fla.). 248 [DOI] 10.1016/j.clim.2022.109213. [PMID] 36566913.
2023
Sirolimus suppresses circulating fibrocytes in idiopathic pulmonary fibrosis in a randomized controlled crossover trial
JCI Insight. 8(8) [DOI] 10.1172/jci.insight.166901. [PMID] 36853800.
2022
3D Single-Breath Chemical Shift Imaging Hyperpolarized Xe-129 MRI of Healthy, CF, IPF, and COPD Subjects
Tomography. 8(5):2574-2587 [DOI] 10.3390/tomography8050215. [PMID] 36287814.
2022
Aspergillus Utilizes Extracellular Heme as an Iron Source During Invasive Pneumonia, Driving Infection Severity
The Journal of Infectious Diseases. 225(10):1811-1821 [DOI] 10.1093/infdis/jiac079. [PMID] 35267014.
2022
Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency.
Respiratory research. 23(1) [DOI] 10.1186/s12931-022-02161-z. [PMID] 36068572.
2022
Computational Modeling of Macrophage Iron Sequestration during Host Defense against Aspergillus.
mSphere. 7(4) [DOI] 10.1128/msphere.00074-22. [PMID] 35862797.
2022
Correlation of alpha-1 antitrypsin levels and exosome associated neutrophil elastase endothelial injury in subjects with SARS-CoV2 infection
PLOS ONE. 17(9) [DOI] 10.1371/journal.pone.0274427. [PMID] 36084115.
2022
CXCL5 gene polymorphisms and coronary collateralization.
American heart journal plus : cardiology research and practice. 23 [DOI] 10.1016/j.ahjo.2022.100220. [PMID] 38560656.
2022
Labile iron accumulation augments T follicular helper cell differentiation
Journal of Clinical Investigation. 132(9) [DOI] 10.1172/jci159472.
2022
Lung transplantation for acute exacerbation of interstitial lung disease
Thorax. 77(4):364-369 [DOI] 10.1136/thoraxjnl-2020-215681. [PMID] 34226204.
2022
Microvascular Dysfunction as a Systemic Disease: A Review of the Evidence.
The American journal of medicine. 135(9):1059-1068 [DOI] 10.1016/j.amjmed.2022.04.006. [PMID] 35472396.
2022
Multi-scale mechanistic modelling of the host defence in invasive aspergillosis reveals leucocyte activation and iron acquisition as drivers of infection outcome.
Journal of the Royal Society, Interface. 19(189) [DOI] 10.1098/rsif.2021.0806. [PMID] 35414216.
2022
Quantitative Computed Tomography: What Clinical Questions Can it Answer in Chronic Lung Disease?
Lung. 200(4):447-455 [DOI] 10.1007/s00408-022-00550-1. [PMID] 35751660.
2021
A modular computational framework for medical digital twins
Proceedings of the National Academy of Sciences. 118(20) [DOI] 10.1073/pnas.2024287118. [PMID] 33972437.
2021
Acute myocarditis during the COVID-19 pandemic: A single center experience.
American heart journal plus : cardiology research and practice. 5 [DOI] 10.1016/j.ahjo.2021.100030. [PMID] 34189492.
2021
Circulating fibrocyte levels correlate with infarct size in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention.
American heart journal plus : cardiology research and practice. 12 [DOI] 10.1016/j.ahjo.2021.100071. [PMID] 35079723.
2021
Clinical Characteristics of Sarcoidosis Patients with Self-Reported Lymphoma: A US Nationwide Registry Study.
Lung. 199(6):611-618 [DOI] 10.1007/s00408-021-00485-z. [PMID] 34665319.
2021
Cyclophosphamide for the treatment of Acute Exacerbation of Interstitial Lung Disease: A Review of the Literature.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. 38(1) [DOI] 10.36141/svdld.v38i1.11271. [PMID] 33867789.
2021
Emergency myelopoiesis contributes to immune cell exhaustion and pulmonary vascular remodelling
British Journal of Pharmacology. 178(1):187-202 [DOI] 10.1111/bph.14945. [PMID] 31793661.
2021
Evaluation of Regional Lung Function in Pulmonary Fibrosis with Xenon-129 MRI.
Tomography (Ann Arbor, Mich.). 7(3):452-465 [DOI] 10.3390/tomography7030039. [PMID] 34564301.
2021
Ex vivo SARS-CoV-2 infection of human lung reveals heterogeneous host defense and therapeutic responses
JCI Insight. 6(18) [DOI] 10.1172/jci.insight.148003. [PMID] 34357881.
2021
Iron Metabolism: An Under Investigated Driver of Renal Pathology in Lupus Nephritis.
Frontiers in medicine. 8 [DOI] 10.3389/fmed.2021.643686. [PMID] 33912577.
2021
Microscopic Polyangiitis With Diffuse Alveolar Hemorrhage and Glomerulonephritis Complicating Acute Influenza Infection.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 27(8S):S618-S619 [DOI] 10.1097/RHU.0000000000001730. [PMID] 33843777.
2021
Neutrophil-Derived Tumor Necrosis Factor Drives Fungal Acute Lung Injury in Chronic Granulomatous Disease.
The Journal of infectious diseases. 224(7):1225-1235 [DOI] 10.1093/infdis/jiab188. [PMID] 33822981.
2021
The natural killer cell activating receptor, NKG2D, is critical to antibody-dependent chronic rejection in heart transplantation
American Journal of Transplantation. 21(11):3550-3560 [DOI] 10.1111/ajt.16690. [PMID] 34014614.
2021
The Role of Bronchoscopic Interventions in the Management of Pneumothorax in Interstitial Lung Disease.
Journal of bronchology & interventional pulmonology. 28(3):238-240 [DOI] 10.1097/LBR.0000000000000731. [PMID] 33208606.
2020
Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo.
Cell communication and signaling : CCS. 18(1) [DOI] 10.1186/s12964-020-00648-0. [PMID] 32887613.
2020
Circulating fibrocytes as prognostic biomarkers of autoimmune interstitial lung disease
ERJ Open Research. 6(4):00481-2020 [DOI] 10.1183/23120541.00481-2020. [PMID] 33263049.
2020
Circulating fibrocytes traffic to the lung in murine acute lung injury and predict outcomes in human acute respiratory distress syndrome: a pilot study.
Molecular medicine (Cambridge, Mass.). 26(1) [DOI] 10.1186/s10020-020-00176-0. [PMID] 32460694.
2019
A checkpoint on innate myeloid cells in pulmonary arterial hypertension.
Pulmonary circulation. 9(1) [DOI] 10.1177/2045894018823528. [PMID] 30562157.
2019
Chemokine signaling axis between endothelial and myeloid cells regulates development of pulmonary hypertension associated with pulmonary fibrosis and hypoxia.
American journal of physiology. Lung cellular and molecular physiology. 317(4):L434-L444 [DOI] 10.1152/ajplung.00156.2019. [PMID] 31364370.
2019
Sporadic Obliterative Bronchiolitis: Case Series and Systematic Review of the Literature.
Mayo Clinic proceedings. Innovations, quality & outcomes. 3(1):86-93 [DOI] 10.1016/j.mayocpiqo.2018.10.003. [PMID] 30899912.
2018
Association between circulating fibrocytes and angiographic coronary collaterals in patients with obstructive coronary artery disease.
American journal of translational research. 10(8):2722-2725 [PMID] 30210709.
2018
Myeloid-Derived Suppressor Cells and Pulmonary Hypertension
International Journal of Molecular Sciences. 19(8) [DOI] 10.3390/ijms19082277. [PMID] 30081463.
2018
Two Siblings With Interstitial Lung Disease.
Chest. 153(4):e75-e79 [DOI] 10.1016/j.chest.2017.12.020. [PMID] 29626972.
2017
Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin.
Infection and immunity. 85(6) [DOI] 10.1128/IAI.00198-17. [PMID] 28396321.
2017
Circulating fibrocytes as biomarkers of impaired lung function in adults with sickle cell disease.
Blood advances. 1(24):2217-2224 [DOI] 10.1182/bloodadvances.2017010777. [PMID] 29296869.
2017
Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia.
JCI insight. 2(6) [DOI] 10.1172/jci.insight.92002. [PMID] 28352667.
2017
Microbiome-mediated neutrophil recruitment via CXCR2 and protection from amebic colitis
PLOS Pathogens. 13(8) [DOI] 10.1371/journal.ppat.1006513. [PMID] 28817707.
2017
Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice.
Free radical biology & medicine. 113:212-223 [DOI] 10.1016/j.freeradbiomed.2017.09.029. [PMID] 28982599.
2016
A computational model of invasive aspergillosis in the lung and the role of iron.
BMC systems biology. 10 [DOI] 10.1186/s12918-016-0275-2. [PMID] 27098278.
2016
Circulating fibrocytes as predictors of adverse events in unstable angina.
Translational research : the journal of laboratory and clinical medicine. 172:73-83.e1 [DOI] 10.1016/j.trsl.2016.02.013. [PMID] 27012475.
2016
Eosinophilic pneumonia associated with pirfenidone therapy.
The European respiratory journal. 48(4):1240-1242 [DOI] 10.1183/13993003.00809-2016. [PMID] 27390279.
2016
Escherichia coli Pyruvate Dehydrogenase Complex Is an Important Component of CXCL10-Mediated Antimicrobial Activity.
Infection and immunity. 84(1):320-8 [DOI] 10.1128/IAI.00552-15. [PMID] 26553462.
2016
Increased circulating fibrocytes are associated with higher reticulocyte percent in children with sickle cell anemia.
Pediatric pulmonology. 51(3):295-9 [DOI] 10.1002/ppul.23248. [PMID] 26130026.
2016
M-CSF Mediates Host Defense during Bacterial Pneumonia by Promoting the Survival of Lung and Liver Mononuclear Phagocytes.
Journal of immunology (Baltimore, Md. : 1950). 196(12):5047-55 [DOI] 10.4049/jimmunol.1600306. [PMID] 27183631.
2016
Number, activation, and differentiation of circulating fibrocytes correlate with asthma severity.
The Journal of allergy and clinical immunology. 137(3):750-7.e3 [DOI] 10.1016/j.jaci.2015.07.037. [PMID] 26371837.
2015
Antimicrobial resistance in hospital-acquired gram-negative bacterial infections.
Chest. 147(5):1413-1421 [DOI] 10.1378/chest.14-2171. [PMID] 25940252.
2015
Hepcidin and Host Defense against Infectious Diseases.
PLoS pathogens. 11(8) [DOI] 10.1371/journal.ppat.1004998. [PMID] 26291319.
2015
Reply: circulating fibrocytes as a biomarker of prognosis in Hermansky-Pudlak syndrome.
American journal of respiratory and critical care medicine. 191(11) [DOI] 10.1164/rccm.201504-0687LE. [PMID] 26029844.
2014
Circulating fibrocytes as biomarker of prognosis in Hermansky-Pudlak syndrome.
American journal of respiratory and critical care medicine. 190(12):1395-401 [DOI] 10.1164/rccm.201407-1287OC. [PMID] 25347450.
2014
CXCR4, but not CXCR7, discriminates metastatic behavior in non-small cell lung cancer cells.
Molecular cancer research : MCR. 12(1):38-47 [DOI] 10.1158/1541-7786.MCR-12-0334. [PMID] 24025971.
2014
Prevalence of obstructive coronary artery disease in patients undergoing lung transplantation: case series and review of the literature.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 84(1):1-6 [DOI] 10.1002/ccd.25261. [PMID] 24136925.
2013
Heterogeneity of lung mononuclear phagocytes during pneumonia: contribution of chemokine receptors.
American journal of physiology. Lung cellular and molecular physiology. 305(10):L702-11 [DOI] 10.1152/ajplung.00194.2013. [PMID] 24056971.
2013
Response to Van Koppen et al.
Journal of hypertension. 31(5):1054-5 [DOI] 10.1097/HJH.0b013e32835fdf99. [PMID] 23552032.
2012
Adenosine A(2B) receptor deficiency promotes host defenses against gram-negative bacterial pneumonia.
American journal of respiratory and critical care medicine. 186(10):1044-50 [DOI] 10.1164/rccm.201204-0622OC. [PMID] 22997203.
2012
Dose-dependent Effect of Statin Therapy on Circulating CXCL12 Levels in Patients with Hyperlipidemia.
Clinical and translational medicine. 1(1) [DOI] 10.1186/2001-1326-1-23. [PMID] 23369699.
2012
Elevated circulating fibrocyte levels in patients with hypertensive heart disease.
Journal of hypertension. 30(9):1856-61 [DOI] 10.1097/HJH.0b013e32835639bb. [PMID] 22796709.
2012
Fibrocytes and the pathogenesis of diffuse parenchymal lung disease.
Fibrogenesis & tissue repair. 5(Suppl 1) [DOI] 10.1186/1755-1536-5-S1-S22. [PMID] 23259468.
2012
Leukocyte compartments in the mouse lung: distinguishing between marginated, interstitial, and alveolar cells in response to injury.
Journal of immunological methods. 375(1-2):100-10 [DOI] 10.1016/j.jim.2011.09.013. [PMID] 21996427.
2012
Neutrophils mediate maturation and efflux of lung dendritic cells in response to Aspergillus fumigatus germ tubes.
Infection and immunity. 80(5):1759-65 [DOI] 10.1128/IAI.00097-12. [PMID] 22392929.
2012
Plasma CXCL12 levels as a predictor of future stroke.
Stroke. 43(12):3382-6 [DOI] 10.1161/STROKEAHA.112.660878. [PMID] 23042661.
2012
Regulation of neutrophil function by adenosine.
Arteriosclerosis, thrombosis, and vascular biology. 32(4):856-64 [DOI] 10.1161/ATVBAHA.111.226845. [PMID] 22423037.
2012
The role of fibrocytes in sickle cell lung disease.
PloS one. 7(3) [DOI] 10.1371/journal.pone.0033702. [PMID] 22442712.
2011
Chemokines as mediators of tumor angiogenesis and neovascularization.
Experimental cell research. 317(5):685-90 [DOI] 10.1016/j.yexcr.2010.10.020. [PMID] 21040721.
2011
Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimicrobial activity against Bacillus anthracis.
Proceedings of the National Academy of Sciences of the United States of America. 108(41):17159-64 [DOI] 10.1073/pnas.1108495108. [PMID] 21949405.
2011
Plasma chemokine levels are associated with the presence and extent of angiographic coronary collaterals in chronic ischemic heart disease.
PloS one. 6(6) [DOI] 10.1371/journal.pone.0021174. [PMID] 21731663.
2011
The role of fibrocytes in fibrotic diseases of the lungs and heart.
Fibrogenesis & tissue repair. 4 [DOI] 10.1186/1755-1536-4-2. [PMID] 21219601.
2010
CXC chemokines in cancer angiogenesis and metastases.
Advances in cancer research. 106:91-111 [DOI] 10.1016/S0065-230X(10)06003-3. [PMID] 20399957.
2010
Fibrocytes: bringing new insights into mechanisms of inflammation and fibrosis.
The international journal of biochemistry & cell biology. 42(4):535-42 [DOI] 10.1016/j.biocel.2009.10.014. [PMID] 19850147.
2010
Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection.
PLoS pathogens. 6(11) [DOI] 10.1371/journal.ppat.1001199. [PMID] 21124994.
2010
Neutropenia enhances lung dendritic cell recruitment in response to Aspergillus via a cytokine-to-chemokine amplification loop.
Journal of immunology (Baltimore, Md. : 1950). 185(10):6190-7 [DOI] 10.4049/jimmunol.1002064. [PMID] 20926800.
2009
Antimicrobial effects of interferon-inducible CXC chemokines against Bacillus anthracis spores and bacilli.
Infection and immunity. 77(4):1664-78 [DOI] 10.1128/IAI.01208-08. [PMID] 19179419.
2009
Early NK cell-derived IFN-{gamma} is essential to host defense in neutropenic invasive aspergillosis.
Journal of immunology (Baltimore, Md. : 1950). 182(7):4306-12 [DOI] 10.4049/jimmunol.0803462. [PMID] 19299730.
2009
Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis.
The international journal of biochemistry & cell biology. 41(8-9):1708-18 [DOI] 10.1016/j.biocel.2009.02.020. [PMID] 19433312.
2009
Innate immunity to Aspergillus species.
Clinical microbiology reviews. 22(4):535-51 [DOI] 10.1128/CMR.00014-09. [PMID] 19822887.
2009
New mechanisms of pulmonary fibrosis.
Chest. 136(5):1364-1370 [DOI] 10.1378/chest.09-0510. [PMID] 19892675.
2009
The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders.
Thrombosis and haemostasis. 101(4):613-8 [PMID] 19350102.
2009
The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis.
Journal of leukocyte biology. 86(5):1111-8 [DOI] 10.1189/jlb.0309132. [PMID] 19581373.
2009
The role of circulating mesenchymal progenitor cells, fibrocytes, in promoting pulmonary fibrosis.
Transactions of the American Clinical and Climatological Association. 120:49-59 [PMID] 19768162.
2008
Chemokines as mediators of neovascularization.
Arteriosclerosis, thrombosis, and vascular biology. 28(11):1928-36 [DOI] 10.1161/ATVBAHA.108.162925. [PMID] 18757292.
2007
Chemokines as mediators of angiogenesis.
Thrombosis and haemostasis. 97(5):755-62 [PMID] 17479186.
2007
Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease.
Biochemical and biophysical research communications. 353(1):104-8 [PMID] 17174272.
2007
Circulating progenitor cells in chronic lung disease.
Expert review of respiratory medicine. 1(1):157-65 [DOI] 10.1586/17476348.1.1.157. [PMID] 20477275.
2007
The role of CC chemokine receptor 6 in host defense in a model of invasive pulmonary aspergillosis.
American journal of respiratory and critical care medicine. 175(11):1165-72 [PMID] 17379855.
2006
Neutrophils regulate airway responses in a model of fungal allergic airways disease.
Journal of immunology (Baltimore, Md. : 1950). 176(4):2538-45 [PMID] 16456015.
2006
The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections.
Journal of immunology (Baltimore, Md. : 1950). 176(5):3233-9 [PMID] 16493084.
2005
Cytokines in host defense against Aspergillus: recent advances.
Medical mycology. 43 Suppl 1:S173-6 [PMID] 16110808.
2005
Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome.
The Journal of clinical investigation. 115(5):1150-62 [PMID] 15864347.
2004
Conditional transgenic models to study chemokine biology.
Methods in molecular biology (Clifton, N.J.). 239:105-22 [PMID] 14573913.
2003
Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis.
The Journal of clinical investigation. 112(12):1862-70 [PMID] 14679181.
2003
Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women.
Journal of the American College of Cardiology. 41(8):1358-63 [PMID] 12706932.
2002
Transient lung-specific expression of the chemokine KC improves outcome in invasive aspergillosis.
American journal of respiratory and critical care medicine. 166(9):1263-8 [PMID] 12403697.
2001
Antifungal and airway remodeling roles for murine monocyte chemoattractant protein-1/CCL2 during pulmonary exposure to Asperigillus fumigatus conidia.
Journal of immunology (Baltimore, Md. : 1950). 166(3):1832-42 [PMID] 11160230.
2001
Impaired pulmonary host defense in mice lacking expression of the CXC chemokine lungkine.
Journal of immunology (Baltimore, Md. : 1950). 166(5):3362-8 [PMID] 11207292.
2001
Spectrum of Aspergillus infection in lung transplant recipients: case series and review of the literature.
Chest. 119(1):169-75 [PMID] 11157600.
2000
Airway remodeling is absent in CCR1-/- mice during chronic fungal allergic airway disease.
Journal of immunology (Baltimore, Md. : 1950). 165(3):1564-72 [PMID] 10903765.
2000
Bacterial clearance and survival are dependent on CXC chemokine receptor-2 ligands in a murine model of pulmonary Nocardia asteroides infection.
Journal of immunology (Baltimore, Md. : 1950). 164(2):908-15 [PMID] 10623839.
2000
Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus.
The American journal of pathology. 156(2):723-32 [PMID] 10666400.
2000
CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia.
Infection and immunity. 68(7):4289-96 [PMID] 10858247.
2000
Cytokines as targets of immunotherapy in bacterial pneumonia.
The Journal of laboratory and clinical medicine. 135(2):129-38 [PMID] 10695657.
2000
Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice.
Journal of immunology (Baltimore, Md. : 1950). 165(5):2603-11 [PMID] 10946288.
2000
Macrophage inflammatory protein-1 alpha is a critical mediator of host defense against invasive pulmonary aspergillosis in neutropenic hosts.
Journal of immunology (Baltimore, Md. : 1950). 165(2):962-8 [PMID] 10878372.
1999
CXC chemokine receptor-2 ligands are necessary components of neutrophil-mediated host defense in invasive pulmonary aspergillosis.
Journal of immunology (Baltimore, Md. : 1950). 163(11):6086-94 [PMID] 10570298.
1999
Intrapulmonary tumor necrosis factor gene therapy increases bacterial clearance and survival in murine gram-negative pneumonia.
Human gene therapy. 10(6):899-909 [PMID] 10223724.
1999
Role of cytokines in pulmonary antimicrobial host defense.
Immunologic research. 20(1):15-27 [PMID] 10467980.
1999
Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis.
Journal of immunology (Baltimore, Md. : 1950). 162(3):1633-40 [PMID] 9973423.
1999
St. Louis encephalitis and the substantia nigra: MR imaging evaluation.
AJNR. American journal of neuroradiology. 20(7):1281-3 [PMID] 10472986.
1999
Use of Animal Models in the Study of Inflammatory Mediators of Pneumonia.
ILAR journal. 40(4):167-174 [PMID] 11533515.

Grants

Nov 2024 ACTIVE
Multiscale modeling of the role of heme during invasive pulmonary aspergillosis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Dec 2023 ACTIVE
Tuning complement-mediated immunity in aspergillosis: a systems medicine approach
Role: Other
Funding: NATL INST OF HLTH NIAID
Jul 2023 ACTIVE
Mechanistic modeling of the innate immune responses of the human lung to understand the inter-individual heterogeneity of COVID-19 pneumonia
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Feb 2023 – Feb 2024
Intersect Fellowship for Computational Scientists and Immunologists
Role: Principal Investigator
Funding: AM ASSN OF IMMUNOLOGISTS
Dec 2022 – Nov 2024
Assessing the Pulmonary Toxicity of Microplastic Fibers Complexed with Azo Dyes
Role: Principal Investigator
Funding: NATL INST OF HLTH NIEHS
Nov 2022 – May 2024
Antiviral Screening
Role: Principal Investigator
Funding: Merck Sharp & Dohme
Jul 2021 ACTIVE
Pyroaeromycoses: fundamental discovery and modeling in an unexplored phenomenon
Role: Principal Investigator
Funding: UF FOUNDATION via KECK FOUNDATION, W.M.
Oct 2020 – Sep 2022
A Multicenter, Randomized-Controlled Trial to Evaluate the Efficacy and Safety of Antithrombotic Therapy for Prevention of Arterial and Venous Thrombotic Complications in Critically-Ill COVID-19 Patients
Role: Principal Investigator
Funding: BRIGHAM AND WOMENS HOSPITAL
Jul 2020 – Jun 2023
Characterization of Toxicity of Airborne ENMs using Direct In Vitro Exposure (DIVE)
Role: Co-Investigator
Funding: AEROSOL DYNAMICS via NATL INST OF HLTH NIEHS
May 2020 – Jun 2024
Multiscale modeling of the battle over iron in invasive lung infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
May 2020 – Aug 2022
Modular design of multiscale models, with an application to the innate immune response to fungal respiratory pathogens
Role: Principal Investigator
Funding: NATL INST OF HLTH NIBIB
Apr 2020 – Apr 2025
CTOA-PULMCOVID
Role: Principal Investigator
Funding: UNIV OF FLORIDA
Jul 2018 – Jun 2022
Circulating fibrocytes as biomarkers of cardiac sarcoidosis
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Jul 2018 – May 2020
Multiscale modeling of the battle over iron in invasive lung infection
Role: Principal Investigator
Funding: UNIV OF CONNECTICUT via NATL INST OF HLTH NIAID
May 2018 – Jan 2025
High throughput 3D printing
Role: Co-Project Director/Principal Investigator
Funding: MERCK SHARP & DOHME
Sep 2017 – May 2020
Modular design of multiscale models, with an application to the innate immune response to fungal respiratory pathogens
Role: Principal Investigator
Funding: UNIV OF CONNECTICUT via NATL INST OF HLTH NIBIB
Jun 2011 ACTIVE
CLINICAL TRIAL OPERATING ACCOUNT
Role: Principal Investigator
Funding: UNIV OF FLORIDA
Jul 2008 – Jun 2021
Pulmonary Med Cystic Fibrosis
Role: Principal Investigator
Funding: UF FOUNDATION

Education

Research Fellowship
2000 · Schering-Plough Research Institute
Research Fellowship
1997-2000 · University of Michigan
Fellowship – Pulmonary and Critical Care Medicine
1996-1999 · University of Michigan
Fellowship – Infectious Diseases
1995-1996 · University of Texas Southwestern Medical Center
Residency – Internal Medicine
1992-1995 · University of Texas Southwestern Medical Center
Medical Degree
1986-1991 · University of Nottingham

Contact Details

Phones:
Business:
(352) 273-8735
Emails:
Addresses:
Business Mailing:
P.O. BOX 100225 JHMHC
GAINESVILLE FL 326100001
Business Street:
1600 SW ARCHER RD M454
GAINESVILLE FL 32610