Lei Jin,
Associate Professor
Department:
MD-PULMONARY MEDICINE
Business Phone:
(352) 294-8495
Business Email:
lei.jin@medicine.ufl.edu
About Lei Jin
Accomplishments
Marie Curie Fellow
2012
·
Seventh Framework Programme, European Commission
Teaching Profile
Courses Taught
2019,2021-2023,2023-2024
GMS5905 Special Topics in Biomedical Sciences
2018
GMS7980 Research for Doctoral Dissertation
2017
VME6934 Topics in Veterinary Medical Sciences
2021-2025
GMS6140 Principles of Immunology
Research Profile
Areas of Interest
- Asthma
- Immune Tolerance
- Inflammation biology
- Metabolism
- vaccines
Publications
Academic Articles
2025
Opposing role for myeloid and smooth muscle cell STING in pulmonary hypertension
JCI Insight.
[DOI] 10.1172/jci.insight.184792.
2025
Transcriptome-guided GLP-1 receptor therapy rescues metabolic and behavioral disruptions in a Bardet-Biedl Syndrome mouse model.
The Journal of clinical investigation.
[DOI] 10.1172/JCI184636.
[PMID] 40233116.
2024
Author response: The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice
.
[DOI] 10.7554/elife.96790.2.sa0.
2024
Author response: The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice
.
[DOI] 10.7554/elife.96790.1.sa3.
2024
Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity.
Cell reports. Medicine.
5(5)
[DOI] 10.1016/j.xcrm.2024.101560.
[PMID] 38729159.
2024
Non–Interferon-Dependent Role of STING Signaling in Pulmonary Hypertension
Arteriosclerosis, Thrombosis, and Vascular Biology.
44(1):124-142
[DOI] 10.1161/atvbaha.123.320121.
2024
The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice
eLife.
13
[DOI] 10.7554/elife.96790.
2024
The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice
eLife.
13
[DOI] 10.7554/elife.96790.3.
2024
The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.10.05.561109.
[PMID] 37886547.
2024
UniParser: Multi-Human Parsing With Unified Correlation Representation Learning.
IEEE transactions on image processing : a publication of the IEEE Signal Processing Society.
33:5159-5171
[DOI] 10.1109/TIP.2024.3456004.
[PMID] 39264771.
2022
MPYS Modulates Fatty Acid Metabolism and Immune Tolerance at Homeostasis Independent of Type I IFNs
The Journal of Immunology.
209(11):2114-2132
[DOI] 10.4049/jimmunol.2200158.
[PMID] 36261171.
2021
cGAS-STING and MyD88 Pathways Synergize in Ly6Chi Monocyte to Promote Streptococcus pneumoniae-Induced Late-Stage Lung IFNγ Production.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.699702.
[PMID] 34512626.
2021
Chitin-derived polymer deacetylation regulates mitochondrial reactive oxygen species dependent cGAS-STING and NLRP3 inflammasome activation
Biomaterials.
275
[DOI] 10.1016/j.biomaterials.2021.120961.
2021
In vivo reprogramming of pathogenic lung TNFR2 + cDC2s by IFNβ inhibits HDM-induced asthma
Science Immunology.
6(61)
[DOI] 10.1126/sciimmunol.abi8472.
[PMID] 34244314.
2021
Monocyte-Derived Dendritic Cells (moDCs) Differentiate into Bcl6+ Mature moDCs to Promote Cyclic di-GMP Vaccine Adjuvant–Induced Memory TH Cells in the Lung
The Journal of Immunology.
206(9):2233-2245
[DOI] 10.4049/jimmunol.2001347.
[PMID] 33879579.
2021
Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD.
Mucosal immunology.
14(2):431-442
[DOI] 10.1038/s41385-020-00344-9.
[PMID] 32968197.
2021
STING and transplantation: can targeting this pathway improve outcomes?
Blood.
137(14):1871-1878
[DOI] 10.1182/blood.2020008911.
[PMID] 33619537.
2021
The Third Man: DNA sensing as espionage in pulmonary vascular health and disease.
Pulmonary circulation.
11(1)
[DOI] 10.1177/2045894021996574.
[PMID] 33738095.
2020
Efficient Induction of Cytotoxic T Cells by Viral Vector Vaccination Requires STING-Dependent DC Functions.
Frontiers in immunology.
11
[DOI] 10.3389/fimmu.2020.01458.
[PMID] 32765505.
2020
Lung IFNAR1hi TNFR2+ cDC2 promotes lung regulatory T cells induction and maintains lung mucosal tolerance at steady state.
Mucosal immunology.
13(4):595-608
[DOI] 10.1038/s41385-020-0254-1.
[PMID] 31959883.
2020
New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice.
Frontiers in immunology.
11
[DOI] 10.3389/fimmu.2020.01674.
[PMID] 32849581.
2020
Obesity and STING1 genotype associate with 23-valent pneumococcal vaccination efficacy
JCI Insight.
5(9)
[DOI] 10.1172/jci.insight.136141.
[PMID] 32376795.
2020
STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets
Science Translational Medicine.
12(552)
[DOI] 10.1126/scitranslmed.aay5006.
[PMID] 32669421.
2020
The Age of Cyclic Dinucleotide Vaccine Adjuvants
Vaccines.
8(3)
[DOI] 10.3390/vaccines8030453.
[PMID] 32823563.
2019
B cell MHC class II signaling: A story of life and death.
Human immunology.
80(1):37-43
[DOI] 10.1016/j.humimm.2018.04.013.
[PMID] 29715484.
2019
Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression.
Glia.
67(7):1254-1276
[DOI] 10.1002/glia.23592.
[PMID] 30680794.
2019
Evaluation of Mucosal and Systemic Vaccine Responses by Cyclic di-GMP (CDG)-adjuvanted Protein Subunit Vaccines.
Bio-protocol.
9(8)
[DOI] 10.21769/BioProtoc.3217.
[PMID] 33655008.
2019
Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.
Nature communications.
10(1)
[DOI] 10.1038/s41467-019-08605-3.
[PMID] 30741923.
2019
Immature lung TNFR2- conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo.
Mucosal immunology.
12(1):277-289
[DOI] 10.1038/s41385-018-0098-0.
[PMID] 30327534.
2019
TMEM173 variants and potential importance to human biology and disease
Genes & Immunity.
20(1):82-89
[DOI] 10.1038/s41435-018-0029-9.
[PMID] 29728611.
2018
The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans.
Infection and immunity.
86(3)
[DOI] 10.1128/IAI.00849-17.
[PMID] 29263110.
2018
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires’ disease in humans
PLOS Pathogens.
14(1)
[DOI] 10.1371/journal.ppat.1006829.
[PMID] 29298342.
2017
Response to Comment on “The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele”
The Journal of Immunology.
198(11):4185-4188
[DOI] 10.4049/jimmunol.1700322.
[PMID] 28533277.
2017
The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele
The Journal of Immunology.
198(2):776-787
[DOI] 10.4049/jimmunol.1601585.
[PMID] 27927967.
2016
A novel pH-enzyme-dependent mesalamine colon-specific delivery system.
Drug design, development and therapy.
10:2021-8
[DOI] 10.2147/DDDT.S107283.
[PMID] 27382255.
2016
Growing tumors induce a local STING dependent Type I IFN response in dendritic cells.
International journal of cancer.
139(6):1350-7
[DOI] 10.1002/ijc.30159.
[PMID] 27116225.
2016
Immunological Functions of the Membrane Proximal Region of MHC Class II Molecules.
F1000Research.
5
[DOI] 10.12688/f1000research.7610.1.
[PMID] 27006762.
2016
The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.
Immunity.
44(3):597-608
[DOI] 10.1016/j.immuni.2016.02.004.
[PMID] 26944200.
2015
Gossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites.
Scientific reports.
5
[DOI] 10.1038/srep14139.
[PMID] 26420475.
2015
The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo.
eLife.
4
[DOI] 10.7554/eLife.06670.
[PMID] 25898005.
2014
Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) in Mycobacterium tuberculosis leads to reduced virulence in a mouse model of infection.
Molecular microbiology.
93(1):65-79
[DOI] 10.1111/mmi.12641.
[PMID] 24806618.
2014
MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3′-5′)-cyclic-di-guanosine-monophosphate in vivo.
Journal of immunology (Baltimore, Md. : 1950).
192(1):492-502
[DOI] 10.4049/jimmunol.1301812.
[PMID] 24307739.
2014
Myeloid-derived suppressor cells are associated with viral persistence and downregulation of TCR ζ chain expression on CD8(+) T cells in chronic hepatitis C patients.
Molecules and cells.
37(1):66-73
[DOI] 10.14348/molcells.2014.2282.
[PMID] 24552712.
2014
Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production.
Nature immunology.
15(6):538-45
[DOI] 10.1038/ni.2888.
[PMID] 24777530.
2013
Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome.
EMBO reports.
14(10):900-6
[DOI] 10.1038/embor.2013.132.
[PMID] 24008845.
2013
HCV-specific interleukin-21+CD4+ T cells responses associated with viral control through the modulation of HCV-specific CD8+ T cells function in chronic hepatitis C patients.
Molecules and cells.
36(4):362-7
[DOI] 10.1007/s10059-013-0181-z.
[PMID] 24170093.
2013
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America.
110(12):E1122-31
[DOI] 10.1073/pnas.1300392110.
[PMID] 23447566.
2013
STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration.
Journal of immunology (Baltimore, Md. : 1950).
190(6):2835-43
[DOI] 10.4049/jimmunol.1201788.
[PMID] 23378430.
2012
SMIP-016 in action: CD37 as a death receptor.
Cancer cell.
21(5):597-598
[DOI] 10.1016/j.ccr.2012.04.034.
[PMID] 22624709.
2012
VISA is required for B cell expression of TLR7.
Journal of immunology (Baltimore, Md. : 1950).
188(1):248-58
[DOI] 10.4049/jimmunol.1100918.
[PMID] 22105994.
2011
MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP.
Journal of immunology (Baltimore, Md. : 1950).
187(5):2595-601
[DOI] 10.4049/jimmunol.1100088.
[PMID] 21813776.
2011
New serum biomarkers for detection of tuberculosis using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry.
Clinical chemistry and laboratory medicine.
49(10):1727-33
[DOI] 10.1515/CCLM.2011.634.
[PMID] 21671803.
2010
Cellular reactive oxygen species inhibit MPYS induction of IFNβ.
PloS one.
5(12)
[DOI] 10.1371/journal.pone.0015142.
[PMID] 21170271.
2010
Microsatellite polymorphisms in intron 2 of the toll-like receptor 2 gene and their association with susceptibility to pulmonary tuberculosis in Han Chinese.
Clinical chemistry and laboratory medicine.
48(6):785-9
[DOI] 10.1515/CCLM.2010.154.
[PMID] 20298136.
2009
Imbalanced intrahepatic cytokine expression of interferon-gamma, tumor necrosis factor-alpha, and interleukin-10 in patients with acute-on-chronic liver failure associated with hepatitis B virus infection.
Journal of clinical gastroenterology.
43(2):182-90
[DOI] 10.1097/MCG.0b013e3181624464.
[PMID] 18633332.
2008
[Nuclear status of day 2 preembryos affects embryo quality and implantation potential].
Zhonghua nan ke xue = National journal of andrology.
14(1):26-9
[PMID] 18297807.
2008
MHC class II structural requirements for the association with Igalpha/beta, and signaling of calcium mobilization and cell death.
Immunology letters.
116(2):184-94
[DOI] 10.1016/j.imlet.2007.11.023.
[PMID] 18194817.
2008
MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals.
Molecular and cellular biology.
28(16):5014-26
[DOI] 10.1128/MCB.00640-08.
[PMID] 18559423.
2008
Relationship between pronuclear scoring and embryo quality and implantation potential in IVF-ET.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
28(2):204-6
[DOI] 10.1007/s11596-008-0223-5.
[PMID] 18480999.
2007
PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors.
Blood.
109(11):4671-8
[PMID] 17272504.
2006
[Comparison between the results of ICSI with fresh and with frozen-thawed sperm obtained by PESA to treat azoospermia].
Zhonghua nan ke xue = National journal of andrology.
12(5):443-5, 449
[PMID] 16755879.
2006
Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B.
Journal of immunology (Baltimore, Md. : 1950).
177(1):739-47
[PMID] 16785573.
2005
[Vitrification of human cleaved embryos in vitro fertilization-embryo transfer].
Zhonghua fu chan ke za zhi.
40(10):682-4
[PMID] 16277900.
2003
[Distribution of HIV-1 coreceptor CX3CR1 allelic polymorphisms in general population, HIV-1 high-risk group and HIV-1 carriers of Chinese indigenous Han and Uygur people].
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi.
24(7):595-8
[PMID] 12975017.
2003
[Distribution of the HIV/AIDS associated CCR5Delta32,CCR2b-64I,SDF1-3’A allelesin Chinese Dai and Chingpaw populations from Dehong autonomous prefecture of Yunnan Province].
Yi chuan = Hereditas.
25(6):655-9
[PMID] 15639953.
2003
[Polymorphism of CXCR4 coding region of human immunodeficiency virus-1 in Chinese Han people].
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology.
17(2):162-4
[PMID] 12870001.
2003
[Preliminary study on the association of chemokine RANTES gene polymorphisms with HIV-1 infection in Chinese Han population].
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi.
24(11):971-5
[PMID] 14687494.
2003
[Single nucleotide polymorphism loci of HIV-1 coreceptor CCR5 gene in Chinese Han people].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics.
20(1):72-4
[PMID] 12579509.
2003
Population survey of CCR5 delta32, CCR5 m303, CCR2b 64I, and SDF1 3’A allele frequencies in indigenous Chinese healthy individuals, and in HIV-1-infected and HIV-1-uninfected individuals in HIV-1 risk groups.
Journal of acquired immune deficiency syndromes (1999).
32(2):124-30
[PMID] 12571520.
2002
[Identification of new mutant sites and 894C deletion variant genotyping of HIV-1 coreceptor CCR5 in indigenous Chinese populations].
Zhonghua yi xue za zhi.
82(21):1468-72
[PMID] 12509908.
2002
Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling.
The Journal of experimental medicine.
195(9):1199-205
[PMID] 11994425.
2002
Two novel mutations of the retinitis pigmentosa GTPase regulator gene in two Chinese families with X-linked retinitis pigmentosa.
Chinese medical journal.
115(6):833-6
[PMID] 12123547.
2000
Identification of two novel mutations (E332X and c1536delC) in the RPGR gene in two Chinese families with X-linked retinitis pigmentosa.
Human mutation.
15(6)
[PMID] 10862103.
Mucosal vaccine adjuvant cyclic di-GMP differentiates lung moDCs into Bcl6+and Bcl6−mature moDCs to induce lung memory CD4+THcells and lung TFHcells respectively
.
[DOI] 10.1101/2020.06.04.135244.
Grants
Apr 2022
ACTIVE
The Function of Host-derived Extracellular Vesicles in Trafficking of Bacterial Antigens to Stimulate the Antibacterial Immune Response
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Jan 2021
ACTIVE
Lung IDO-1+ TNFR2+ cDC2 subset in control of lung mucosal tolerance: Mechanism and Application
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Sep 2020
– Aug 2021
The American Association of Immunologists Careers in Immunology Fellowship Program
Role: Principal Investigator
Funding: AM ASSN OF IMMUNOLOGISTS
Jun 2018
– May 2021
Mechanisms of STING-dependent IFNgamma production during pulmonary pneumococcal infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jun 2016
– May 2019
Impact of Human STING Variants on Pneumococcal Vaccine Effectiveness
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
May 2016
– Nov 2021
Mechanisms of STING-Mediated Mucosal Vaccine Adjuvant Activity of Cyclic di-GMP
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Education
Postdoctoral Researcher
2012
·
National Jewish Health
Ph.D.
2004
·
Tufts University
Contact Details
Phones:
- Business:
- (352) 294-8495
Emails:
- Business:
- lei.jin@medicine.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100225
1600 SW ARCHER RD
GAINESVILLE FL 32610