Scott Brakenridge,
Associate Professor
Teaching Profile
Courses Taught
2018
MDC7600 Surgery Clerkship
2018
MDC7602 Senior Surgery Clerk
2018
MDC6001 Intro Clin Practice
Publications
Academic Articles
2025
A randomized, double-blind, placebo-controlled trial of IL-7 in critically ill patients with COVID-19.
JCI insight.
10(6)
[DOI] 10.1172/jci.insight.189150.
[PMID] 39903535.
2025
Determining potential immunomodulatory drug efficacy in sepsis using ELISpot.
Scientific reports.
15(1)
[DOI] 10.1038/s41598-025-92016-6.
[PMID] 40251188.
2025
High affinity CD16 polymorphism associated with reduced risk of severe COVID-19.
JCI insight.
[DOI] 10.1172/jci.insight.191314.
[PMID] 40402577.
2025
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients.
Nature communications.
16(1)
[DOI] 10.1038/s41467-025-55823-z.
[PMID] 39794319.
2025
Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2025.02.12.25322164.
[PMID] 39990570.
2024
Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot.
JCI insight.
9(2)
[DOI] 10.1172/jci.insight.175785.
[PMID] 38100268.
2024
Development and optimization of a diluted whole blood ELISpot assay to test immune function.
Journal of immunological methods.
533
[DOI] 10.1016/j.jim.2024.113743.
[PMID] 39147231.
2024
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.
Nature communications.
15(1)
[DOI] 10.1038/s41467-023-44090-5.
[PMID] 38172101.
2024
Multiple organ failure: What you need to know.
The journal of trauma and acute care surgery.
[DOI] 10.1097/TA.0000000000004419.
[PMID] 39225733.
2024
Predicting high-intensity resuscitation needs in injured patients in the post-hemostasis phase of care following intervention.
The journal of trauma and acute care surgery.
96(4):611-617
[DOI] 10.1097/TA.0000000000004156.
[PMID] 37872673.
2024
Severe trauma leads to sustained muscle loss, induced frailty, and distinct temporal changes in myokine and chemokine profiles of older patients.
Surgery.
176(5):1516-1524
[DOI] 10.1016/j.surg.2024.07.031.
[PMID] 39179433.
2024
Surviving septic patients endotyped with a functional assay demonstrate active immune responses.
Frontiers in immunology.
15
[DOI] 10.3389/fimmu.2024.1418613.
[PMID] 39469706.
2024
TEMPORAL CHANGES IN INNATE AND ADAPTIVE IMMUNITY DURING SEPSIS AS DETERMINED BY ELISPOT.
Shock (Augusta, Ga.).
62(2):255-264
[DOI] 10.1097/SHK.0000000000002377.
[PMID] 38754032.
2024
Weight-based enoxaparin thromboprophylaxis in young trauma patients: analysis of the CLOTT-1 registry.
Trauma surgery & acute care open.
9(1)
[DOI] 10.1136/tsaco-2023-001230.
[PMID] 38420604.
2023
Adverse Long-Term Outcomes and an Immune Suppressed Endotype in Sepsis Patients with Reduced Interferon-γELISpot: A Multicenter, Prospective Observational Study.
medRxiv : the preprint server for health sciences.
[DOI] 10.1101/2023.09.13.23295360.
[PMID] 37745385.
2023
Chronic Critical Illness in Patients With Sepsis is Associated With Persistent Anemia, Inflammation, and Impaired Functional Outcomes.
The American surgeon.
89(6):2563-2571
[DOI] 10.1177/00031348221104252.
[PMID] 35593749.
2023
Corrigendum to “Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study” [eBioMedicine 83 (2022) 104208].
EBioMedicine.
98
[DOI] 10.1016/j.ebiom.2023.104860.
[PMID] 37918220.
2023
Defining critical illness using immunological endotypes in patients with and without of sepsis: A cohort study.
Research square.
[DOI] 10.21203/rs.3.rs-2874506/v1.
[PMID] 37214996.
2023
Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study.
Critical care (London, England).
27(1)
[DOI] 10.1186/s13054-023-04571-x.
[PMID] 37474944.
2023
Defining Posttraumatic Sepsis for Population-Level Research.
JAMA network open.
6(1)
[DOI] 10.1001/jamanetworkopen.2022.51445.
[PMID] 36652245.
2023
Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial.
Annals of intensive care.
13(1)
[DOI] 10.1186/s13613-023-01109-w.
[PMID] 36906875.
2023
PREHOSPITAL CRYSTALLOID RESUSCITATION: PRACTICE VARIATION AND ASSOCIATIONS WITH CLINICAL OUTCOMES.
Shock (Augusta, Ga.).
59(1):28-33
[DOI] 10.1097/SHK.0000000000002039.
[PMID] 36703275.
2023
The persistent inflammation, immunosuppression, and catabolism syndrome 10 years later.
The journal of trauma and acute care surgery.
95(5):790-799
[DOI] 10.1097/TA.0000000000004087.
[PMID] 37561664.
2022
A core outcome set for damage control laparotomy via modified Delphi method.
Trauma surgery & acute care open.
7(1)
[DOI] 10.1136/tsaco-2021-000821.
[PMID] 35047673.
2022
Challenging Traditional Paradigms in Posttraumatic Pulmonary Thromboembolism.
JAMA surgery.
157(2)
[DOI] 10.1001/jamasurg.2021.6356.
[PMID] 34910098.
2022
Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study.
Annals of surgery.
275(6):1184-1193
[DOI] 10.1097/SLA.0000000000004360.
[PMID] 33196489.
2022
Estimated vs measured energy expenditure in ventilated surgical-trauma critically ill patients.
JPEN. Journal of parenteral and enteral nutrition.
46(6):1431-1440
[DOI] 10.1002/jpen.2314.
[PMID] 34921708.
2022
Evaluation of a Multivalent Transcriptomic Metric for Diagnosing Surgical Sepsis and Estimating Mortality Among Critically Ill Patients.
JAMA network open.
5(7)
[DOI] 10.1001/jamanetworkopen.2022.21520.
[PMID] 35819783.
2022
Ineffective Erythropoietin Response to Anemia in Sepsis.
Surgical infections.
23(2):142-149
[DOI] 10.1089/sur.2021.152.
[PMID] 34958257.
2022
Nonocclusive mesenteric ischemia: A rare but lethal complication of enteral nutrition in critically ill patients.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.
37(3):715-726
[DOI] 10.1002/ncp.10761.
[PMID] 34462980.
2022
Older Adults Demonstrate Biomarker Evidence of the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) After Sepsis.
The journals of gerontology. Series A, Biological sciences and medical sciences.
77(1):188-196
[DOI] 10.1093/gerona/glab080.
[PMID] 33721883.
2022
Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study.
EBioMedicine.
83
[DOI] 10.1016/j.ebiom.2022.104208.
[PMID] 35952496.
2022
Sex differences associate with late microbiome alterations after murine surgical sepsis.
The journal of trauma and acute care surgery.
93(2):137-146
[DOI] 10.1097/TA.0000000000003599.
[PMID] 35324554.
2022
Transcriptomic Changes Within Human Bone Marrow After Severe Trauma.
Shock (Augusta, Ga.).
57(1):24-30
[DOI] 10.1097/SHK.0000000000001826.
[PMID] 34172608.
2021
A Transcriptomic Severity Metric That Predicts Clinical Outcomes in Critically Ill Surgical Sepsis Patients.
Critical care explorations.
3(10)
[DOI] 10.1097/CCE.0000000000000554.
[PMID] 34671746.
2021
A Whole Blood Enzyme-Linked Immunospot Assay for Functional Immune Endotyping of Septic Patients.
Journal of immunology (Baltimore, Md. : 1950).
206(1):23-36
[DOI] 10.4049/jimmunol.2001088.
[PMID] 33239423.
2021
Association of Postoperative Clinical Outcomes With Sarcopenia, Frailty, and Nutritional Status in Older Patients With Colorectal Cancer: Protocol for a Prospective Cohort Study.
JMIR research protocols.
10(8)
[DOI] 10.2196/16846.
[PMID] 34402798.
2021
Biomarker Evidence of the Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS) in Chronic Critical Illness (CCI) After Surgical Sepsis.
Annals of surgery.
274(4):664-673
[DOI] 10.1097/SLA.0000000000005067.
[PMID] 34506322.
2021
Chronic critical illness after hypothermia in trauma patients.
Trauma surgery & acute care open.
6(1)
[DOI] 10.1136/tsaco-2021-000747.
[PMID] 34423134.
2021
Chronic Critical Illness Elicits a Unique Circulating Leukocyte Transcriptome in Sepsis Survivors.
Journal of clinical medicine.
10(15)
[DOI] 10.3390/jcm10153211.
[PMID] 34361995.
2021
Distinct immunologic endotypes are associated with clinical trajectory after severe blunt trauma and hemorrhagic shock.
The journal of trauma and acute care surgery.
90(2):257-267
[DOI] 10.1097/TA.0000000000003029.
[PMID] 33214489.
2021
Enteral Nutrition Administration Record Prescribing Process Using Computerized Order Entry: A New Paradigm and Opportunities to Improve Outcomes in Critically Ill Patients.
JPEN. Journal of parenteral and enteral nutrition.
45(3):507-517
[DOI] 10.1002/jpen.1870.
[PMID] 32384191.
2021
Identification of unique microRNA expression patterns in bone marrow hematopoietic stem and progenitor cells after hemorrhagic shock and multiple injuries in young and old adult mice.
The journal of trauma and acute care surgery.
91(4):692-699
[DOI] 10.1097/TA.0000000000003350.
[PMID] 34252063.
2021
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study
Science Immunology.
6(62)
[DOI] 10.1126/sciimmunol.abf3733.
[PMID] 34376480.
2021
In Vitro-Administered Dexamethasone Suppresses T Cell Function With Reversal by Interleukin-7 in Coronavirus Disease 2019.
Critical care explorations.
3(4)
[DOI] 10.1097/CCE.0000000000000378.
[PMID] 33834168.
2021
Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case Report.
Critical care explorations.
3(7)
[DOI] 10.1097/CCE.0000000000000500.
[PMID] 34345826.
2021
Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course Analysis.
Frontiers in immunology.
12
[DOI] 10.3389/fimmu.2021.792448.
[PMID] 34956225.
2021
Pathophysiology and Treatment Strategies of Acute Myopathy and Muscle Wasting after Sepsis.
Journal of clinical medicine.
10(9)
[DOI] 10.3390/jcm10091874.
[PMID] 33926035.
2021
Resolution of organ dysfunction as a predictor of long-term survival in necrotizing soft tissue infections: Analysis of the AB103 Clinical Composite Endpoint Study in Necrotizing Soft Tissue Infections trial and a retrospective claims database-linked chart study.
The journal of trauma and acute care surgery.
91(2):384-392
[DOI] 10.1097/TA.0000000000003183.
[PMID] 33797490.
2021
Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice.
Shock (Augusta, Ga.).
55(4):519-525
[DOI] 10.1097/SHK.0000000000001648.
[PMID] 32826817.
2021
Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research.
Critical care explorations.
3(3)
[DOI] 10.1097/CCE.0000000000000374.
[PMID] 33786450.
2021
Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study.
Shock (Augusta, Ga.).
55(5):587-595
[DOI] 10.1097/SHK.0000000000001671.
[PMID] 33021571.
2021
The Effect of Aging Physiology on Critical Care.
Critical care clinics.
37(1):135-150
[DOI] 10.1016/j.ccc.2020.08.006.
[PMID] 33190766.
2021
The impact of sarcopenia and acute muscle mass loss on long-term outcomes in critically ill patients with intra-abdominal sepsis.
Journal of cachexia, sarcopenia and muscle.
12(5):1203-1213
[DOI] 10.1002/jcsm.12752.
[PMID] 34196134.
2021
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
35(2)
[DOI] 10.1096/fj.202002150R.
[PMID] 33140449.
2020
Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes.
American journal of surgery.
220(6):1467-1474
[DOI] 10.1016/j.amjsurg.2020.07.016.
[PMID] 32807383.
2020
Artificial Intelligence and Surgical Decision-making.
JAMA surgery.
155(2):148-158
[DOI] 10.1001/jamasurg.2019.4917.
[PMID] 31825465.
2020
Audiovisual Modules to Enhance Informed Consent in the ICU: A Pilot Study.
Critical care explorations.
2(12)
[DOI] 10.1097/CCE.0000000000000278.
[PMID] 33251517.
2020
Delayed interhospital transfer of critically ill patients with surgical sepsis.
The journal of trauma and acute care surgery.
88(1):169-175
[DOI] 10.1097/TA.0000000000002476.
[PMID] 31856021.
2020
Discovery and Validation of Urinary Molecular Signature of Early Sepsis.
Critical care explorations.
2(10)
[DOI] 10.1097/CCE.0000000000000195.
[PMID] 33063018.
2020
Evaluation and management of blunt cerebrovascular injury: A practice management guideline from the Eastern Association for the Surgery of Trauma.
The journal of trauma and acute care surgery.
88(6):875-887
[DOI] 10.1097/TA.0000000000002668.
[PMID] 32176167.
2020
Identification of Unique mRNA and miRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells After Trauma in Older Adults.
Frontiers in immunology.
11
[DOI] 10.3389/fimmu.2020.01289.
[PMID] 32670283.
2020
Immunological Endotyping of Chronic Critical Illness After Severe Sepsis.
Frontiers in medicine.
7
[DOI] 10.3389/fmed.2020.616694.
[PMID] 33659259.
2020
Immunotherapies for COVID-19: lessons learned from sepsis.
The Lancet. Respiratory medicine.
8(10):946-949
[DOI] 10.1016/S2213-2600(20)30217-4.
[PMID] 32444269.
2020
Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress.
Shock (Augusta, Ga.).
54(4):482-487
[DOI] 10.1097/SHK.0000000000001506.
[PMID] 31904616.
2020
Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.
Journal of the American Geriatrics Society.
68(9):1962-1969
[DOI] 10.1111/jgs.16435.
[PMID] 32294254.
2020
Persistently increased cell-free DNA concentrations only modestly contribute to outcome and host response in sepsis survivors with chronic critical illness.
Surgery.
167(3):646-652
[DOI] 10.1016/j.surg.2019.11.018.
[PMID] 31898953.
2020
Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study.
Critical care (London, England).
24(1)
[DOI] 10.1186/s13054-020-02917-3.
[PMID] 32381107.
2020
Prospective Validation of a Transcriptomic Metric in Severe Trauma.
Annals of surgery.
271(5):802-810
[DOI] 10.1097/SLA.0000000000003204.
[PMID] 30688688.
2020
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections.
JCI insight.
5(17)
[DOI] 10.1172/jci.insight.140329.
[PMID] 32687484.
2020
Vitamin D status is associated with hepcidin and hemoglobin concentrations in patients with severe traumatic injury.
The journal of trauma and acute care surgery.
89(6):1124-1130
[DOI] 10.1097/TA.0000000000002895.
[PMID] 32769953.
2020
What’s New in Shock, September 2020?
Shock (Augusta, Ga.).
54(3):277-279
[DOI] 10.1097/SHK.0000000000001588.
[PMID] 32796495.
2019
Cardiac pseudoaneurysm following non-operative management after penetrating thoracoabdominal trauma and pericardial window.
The journal of trauma and acute care surgery.
86(4):755-757
[DOI] 10.1097/TA.0000000000002189.
[PMID] 30629012.
2019
Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma.
Scientific reports.
9(1)
[DOI] 10.1038/s41598-019-50044-z.
[PMID] 31541163.
2019
Current Epidemiology of Surgical Sepsis: Discordance Between Inpatient Mortality and 1-year Outcomes.
Annals of surgery.
270(3):502-510
[DOI] 10.1097/SLA.0000000000003458.
[PMID] 31356275.
2019
Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab.
Intensive care medicine.
45(10):1360-1371
[DOI] 10.1007/s00134-019-05704-z.
[PMID] 31576433.
2019
Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559).
Critical care medicine.
47(5):632-642
[DOI] 10.1097/CCM.0000000000003685.
[PMID] 30747773.
2019
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.
Critical care (London, England).
23(1)
[DOI] 10.1186/s13054-019-2628-x.
[PMID] 31722736.
2019
Occult bowel injury after blunt abdominal trauma.
American journal of surgery.
218(2):266-270
[DOI] 10.1016/j.amjsurg.2018.11.018.
[PMID] 30509454.
2019
Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.
Critical care medicine.
47(11):e919-e929
[DOI] 10.1097/CCM.0000000000003926.
[PMID] 31389840.
2019
Persistent inflammation and anemia among critically ill septic patients.
The journal of trauma and acute care surgery.
86(2):260-267
[DOI] 10.1097/TA.0000000000002147.
[PMID] 30489504.
2019
Persistently Elevated Glucagon-Like Peptide-1 Levels among Critically Ill Surgical Patients after Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes.
Journal of the American College of Surgeons.
229(1):58-67.e1
[DOI] 10.1016/j.jamcollsurg.2019.04.014.
[PMID] 30991107.
2019
Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors.
Critical care (London, England).
23(1)
[DOI] 10.1186/s13054-019-2505-7.
[PMID] 31234943.
2019
The authors reply.
Critical care medicine.
47(9):e788-e789
[DOI] 10.1097/CCM.0000000000003887.
[PMID] 31415323.
2019
The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs.
Critical care medicine.
47(4):566-573
[DOI] 10.1097/CCM.0000000000003655.
[PMID] 30664526.
2019
The Impact of Prior Laparotomy and Intra-abdominal Adhesions on Bowel and Mesenteric Injury Following Blunt Abdominal Trauma.
World journal of surgery.
43(2):457-465
[DOI] 10.1007/s00268-018-4792-6.
[PMID] 30225563.
2019
The impact of standardized protocol implementation for surgical damage control and temporary abdominal closure after emergent laparotomy.
The journal of trauma and acute care surgery.
86(4):670-678
[DOI] 10.1097/TA.0000000000002170.
[PMID] 30562327.
2019
Trauma Surgeon and Palliative Care Physician Attitudes Regarding Goals-of-Care Delineation for Injured Geriatric Patients.
The American journal of hospice & palliative care.
36(8):669-674
[DOI] 10.1177/1049909118823182.
[PMID] 30614253.
2018
A protocol for non-operative management of uncomplicated appendicitis.
The journal of trauma and acute care surgery.
84(2):358-364
[DOI] 10.1097/TA.0000000000001709.
[PMID] 29370051.
2018
Activity and Circadian Rhythm of Sepsis Patients in the Intensive Care Unit.
… IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics.
2018:17-20
[DOI] 10.1109/BHI.2018.8333359.
[PMID] 30411088.
2018
Anemia and blood transfusion in elderly trauma patients.
The Journal of surgical research.
229:288-293
[DOI] 10.1016/j.jss.2018.04.021.
[PMID] 29937004.
2018
Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.
The journal of trauma and acute care surgery.
84(2):342-349
[DOI] 10.1097/TA.0000000000001758.
[PMID] 29251709.
2018
Burn Surgeon and Palliative Care Physician Attitudes Regarding Goals of Care Delineation for Burned Geriatric Patients.
Journal of burn care & research : official publication of the American Burn Association.
39(6):1000-1005
[DOI] 10.1093/jbcr/iry027.
[PMID] 29771351.
2018
Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
Frontiers in immunology.
9
[DOI] 10.3389/fimmu.2018.01511.
[PMID] 30013565.
2018
Chronic Critical Illness: Application of What We Know.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.
33(1):39-45
[DOI] 10.1002/ncp.10024.
[PMID] 29323761.
2018
Effect of Time to Operation on Value of Care in Acute Care Surgery.
World journal of surgery.
42(8):2356-2363
[DOI] 10.1007/s00268-018-4476-2.
[PMID] 29352339.
2018
Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis.
Shock (Augusta, Ga.).
49(3):249-258
[DOI] 10.1097/SHK.0000000000000981.
[PMID] 28885387.
2018
Hypertonic saline resuscitation after emergent laparotomy and temporary abdominal closure.
The journal of trauma and acute care surgery.
84(2):350-357
[DOI] 10.1097/TA.0000000000001730.
[PMID] 29140948.
2018
Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.
Frontiers in immunology.
9
[DOI] 10.3389/fimmu.2018.00595.
[PMID] 29670613.
2018
Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.
Surgery.
164(2):178-184
[DOI] 10.1016/j.surg.2018.04.011.
[PMID] 29807651.
2018
Persistent injury-associated anemia and aging: Novel insights.
The journal of trauma and acute care surgery.
84(3):490-496
[DOI] 10.1097/TA.0000000000001766.
[PMID] 29466280.
2018
Persistent injury-associated anemia in aged rats.
Experimental gerontology.
103:63-68
[DOI] 10.1016/j.exger.2018.01.001.
[PMID] 29307734.
2018
Resuscitative Endovascular Balloon Occlusion of the Aorta: Implementation and Preliminary Results at an Academic Level I Trauma Center.
Journal of the American College of Surgeons.
227(1):127-133
[DOI] 10.1016/j.jamcollsurg.2018.03.042.
[PMID] 29709584.
2018
Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults.
PloS one.
13(10)
[DOI] 10.1371/journal.pone.0205327.
[PMID] 30300408.
2018
Successful nonoperative management of uncomplicated appendicitis: predictors and outcomes.
The Journal of surgical research.
222:212-218.e2
[DOI] 10.1016/j.jss.2017.10.006.
[PMID] 29146455.
2018
The effects of beta blockade and clonidine on persistent injury-associated anemia.
The Journal of surgical research.
230:175-180
[DOI] 10.1016/j.jss.2018.06.001.
[PMID] 29960715.
2018
The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients.
The journal of trauma and acute care surgery.
85(2):247-255
[DOI] 10.1097/TA.0000000000001921.
[PMID] 29613958.
2018
The Postinjury Inflammatory State and the Bone Marrow Response to Anemia.
American journal of respiratory and critical care medicine.
198(5):629-638
[DOI] 10.1164/rccm.201712-2536OC.
[PMID] 29768025.
2018
Variations in institutional review board processes and consent requirements for trauma research: an EAST multicenter survey.
Trauma surgery & acute care open.
3(1)
[DOI] 10.1136/tsaco-2018-000176.
[PMID] 29862323.
2017
A comparison of prognosis calculators for geriatric trauma: A Prognostic Assessment of Life and Limitations After Trauma in the Elderly consortium study.
The journal of trauma and acute care surgery.
83(1):90-96
[DOI] 10.1097/TA.0000000000001506.
[PMID] 28422904.
2017
Acute Kidney Injury Following Exploratory Laparotomy and Temporary Abdominal Closure.
Shock (Augusta, Ga.).
48(1):5-10
[DOI] 10.1097/SHK.0000000000000825.
[PMID] 28009772.
2017
Antibiotics May be Safely Discontinued Within One Week of Percutaneous Cholecystostomy.
World journal of surgery.
41(5):1239-1245
[DOI] 10.1007/s00268-016-3861-y.
[PMID] 28050668.
2017
Characterization of hypoalbuminemia following temporary abdominal closure.
The journal of trauma and acute care surgery.
83(4):650-656
[DOI] 10.1097/TA.0000000000001553.
[PMID] 28837537.
2017
Computed tomography evidence of fluid in the hernia sac predicts surgical site infection following mesh repair of acutely incarcerated ventral and groin hernias.
The journal of trauma and acute care surgery.
83(1):170-174
[DOI] 10.1097/TA.0000000000001503.
[PMID] 28426559.
2017
Early bronchoalveolar lavage for intubated trauma patients with TBI or chest trauma.
Journal of critical care.
39:78-82
[DOI] 10.1016/j.jcrc.2017.02.010.
[PMID] 28231518.
2017
Emergent laparotomy and temporary abdominal closure for the cirrhotic patient.
The Journal of surgical research.
210:108-114
[DOI] 10.1016/j.jss.2016.11.013.
[PMID] 28457316.
2017
Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock.
Annals of surgery.
265(4):827-834
[DOI] 10.1097/SLA.0000000000001783.
[PMID] 27163951.
2017
Improved outcomes following implementation of an acute gastrointestinal bleeding multidisciplinary protocol.
The journal of trauma and acute care surgery.
83(1):41-46
[DOI] 10.1097/TA.0000000000001295.
[PMID] 27779592.
2017
Neural network prediction of severe lower intestinal bleeding and the need for surgical intervention.
The Journal of surgical research.
212:42-47
[DOI] 10.1016/j.jss.2016.12.032.
[PMID] 28550920.
2017
Persistent Inflammation, Immunosuppression and Catabolism Syndrome.
Critical care clinics.
33(2):245-258
[DOI] 10.1016/j.ccc.2016.12.001.
[PMID] 28284293.
2017
Predicting appendiceal tumors among patients with appendicitis.
The journal of trauma and acute care surgery.
82(4):771-775
[DOI] 10.1097/TA.0000000000001378.
[PMID] 28099380.
2017
Routine surveillance cholangiography after percutaneous cholecystostomy delays drain removal and cholecystectomy.
The journal of trauma and acute care surgery.
82(2):351-355
[DOI] 10.1097/TA.0000000000001315.
[PMID] 27893641.
2017
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.
BMJ open.
7(7)
[DOI] 10.1136/bmjopen-2016-015136.
[PMID] 28765125.
2017
Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome.
Critical care medicine.
45(2):253-262
[DOI] 10.1097/CCM.0000000000002074.
[PMID] 27632674.
2017
Temporary abdominal closure for trauma and intra-abdominal sepsis: Different patients, different outcomes.
The journal of trauma and acute care surgery.
82(2):345-350
[DOI] 10.1097/TA.0000000000001283.
[PMID] 27787442.
2017
The authors reply.
Critical care medicine.
45(7):e740-e741
[DOI] 10.1097/CCM.0000000000002469.
[PMID] 28622238.
2017
The effects of red cell transfusion donor age on nosocomial infection among trauma patients.
American journal of surgery.
214(4):672-676
[DOI] 10.1016/j.amjsurg.2017.07.004.
[PMID] 28720216.
2017
The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two Level-One Trauma Centers.
Critical care medicine.
45(12):1989-1996
[DOI] 10.1097/CCM.0000000000002697.
[PMID] 28837430.
2017
Validation of a Geriatric Trauma Prognosis Calculator: A P.A.L.Li.A.T.E. Consortium Study.
Journal of the American Geriatrics Society.
65(10):2302-2307
[DOI] 10.1111/jgs.15009.
[PMID] 28804877.
2016
Intubated Trauma Patients Receiving Prolonged Antibiotics for Pneumonia despite Negative Cultures: Predictors and Outcomes.
Surgical infections.
17(6):766-772
[PMID] 27635693.
2016
Multicenter external validation of the Geriatric Trauma Outcome Score: A study by the Prognostic Assessment of Life and Limitations After Trauma in the Elderly (PALLIATE) consortium.
The journal of trauma and acute care surgery.
80(2):204-9
[DOI] 10.1097/TA.0000000000000926.
[PMID] 26595708.
2016
Nutritional Support in the Setting of Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (Pics)
Current Surgery Reports.
4(9)
[DOI] 10.1007/s40137-016-0152-3.
2016
Patterns of gene expression among murine models of hemorrhagic shock/trauma and sepsis.
Physiological genomics.
48(2):135-44
[DOI] 10.1152/physiolgenomics.00072.2015.
[PMID] 26578697.
2016
Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock.
The journal of trauma and acute care surgery.
81(3):478-85
[DOI] 10.1097/TA.0000000000001113.
[PMID] 27306446.
2016
The long-term burden of severe sepsis and septic shock: Sepsis recidivism and organ dysfunction.
The journal of trauma and acute care surgery.
81(3):525-32
[DOI] 10.1097/TA.0000000000001135.
[PMID] 27398984.
2015
A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged.
Journal of immunology (Baltimore, Md. : 1950).
195(5):2396-407
[DOI] 10.4049/jimmunol.1500984.
[PMID] 26246141.
2015
A protocol for the management of adhesive small bowel obstruction.
The journal of trauma and acute care surgery.
78(1):13-9; discussion 19
[DOI] 10.1097/TA.0000000000000491.
[PMID] 25539198.
2015
Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.
Critical care (London, England).
19(1)
[DOI] 10.1186/s13054-015-0788-x.
[PMID] 25880307.
2015
Blunt Trauma Releases Cell Free Nucleic Acids, But Its Prognostic Relevance Does Not Surface Until the Following Day.
Shock.
43(6, 1)
2015
Evaluation and management of blunt traumatic aortic injury: a practice management guideline from the Eastern Association for the Surgery of Trauma.
The journal of trauma and acute care surgery.
78(1):136-46
[DOI] 10.1097/TA.0000000000000470.
[PMID] 25539215.
2015
Evaluation and management of blunt traumatic aortic injury: a practice management guideline from the Eastern Association for the Surgery of Trauma.
Journal of trauma nursing : the official journal of the Society of Trauma Nurses.
22(2):99-110
[DOI] 10.1097/JTN.0000000000000118.
[PMID] 25768967.
2015
Human Myeloid Derived Suppressor Cells Induce Immune Suppression After Severe Sepsis
Shock.
43(6, 1)
2015
Successful implementation of a packed red blood cell and fresh frozen plasma transfusion protocol in the surgical intensive care unit.
PloS one.
10(5)
[DOI] 10.1371/journal.pone.0126895.
[PMID] 26010247.
2015
The Genomic Response After Burn Injury Predicts Organ Dysfunction and Mortality
Shock.
43(6, 1)
2014
A Comparison of the Leukocyte Genomic Responses To Sterile Or Infectious Inflammation
Shock.
41(2)
2014
Advanced Age Is An Independent Predictor of Complicated Outcomes and Mortality Among Severely Injured Pateints in Hemorrhagic Shock
Shock.
41(2)
2014
Genomic Analysis of Individual Leukocyte Populations After Severe Trauma
Shock.
41(2)
2014
Inadequate Pmn Chemokine Receptor Expression After Polymicrobial Abdominal Sepsis Contributes To Defective Pmn Chemotaxis in the Aged
Shock.
41(2)
2014
The Female Transcriptomic Response After Severe Trauma Is Different From That of Males
Shock.
41(2)
2014
The Lung Neutrophil Transcriptome After Trauma Influences the Worse Outcomes of the Old To Pneumonia
Critical Care Medicine.
42(12, S)
2014
Variability is the standard: the management of venous thromboembolic disease following trauma
Journal of Trauma and Acute Care Surgery.
76(1):213-216
2013
Comparing clinical predictors of deep venous thrombosis versus pulmonary embolus after severe injury: a new paradigm for posttraumatic venous thromboembolism?
The journal of trauma and acute care surgery.
74(5):1231-7; discussion 1237
[DOI] 10.1097/TA.0b013e31828cc9a0.
[PMID] 23609272.
2013
Limb salvage after complex repairs of extremity arterial injuries is independent of surgical specialty training.
The journal of trauma and acute care surgery.
74(3):716-23; discussion 723
[DOI] 10.1097/TA.0b013e3182827035.
[PMID] 23425727.
2012
A randomized, double-blinded, placebo-controlled pilot trial of anticoagulation in low-risk traumatic brain injury: The Delayed Versus Early Enoxaparin Prophylaxis I (DEEP I) study.
The journal of trauma and acute care surgery.
73(6):1434-41
[DOI] 10.1097/TA.0b013e31825ac49e.
[PMID] 22914079.
2012
Changes in massive transfusion over time: An early shift in the right direction?
.
72(1):106-111
2011
Early blood product and crystalloid resuscitation: Risk association with multiple organ dysfunction after severe blunt traumatic injury
.
71(2):299-305
2011
Early blood product and crystalloid volume resuscitation: risk association with multiple organ dysfunction after severe blunt traumatic injury.
The Journal of trauma.
71(2):299-305
[DOI] 10.1097/TA.0b013e318224d328.
[PMID] 21825930.
2011
Outcomes and long term follow up after emergent cricothyroidotomy: Is routine conversion to tracheostomy necessary?
American Journal of Surgery.
77:1707-1711
2011
Outcomes and long term follow-up after emergent cricothyroidotomy: is routine conversion to tracheostomy necessary?
The American surgeon.
77(12):1707-11
[PMID] 22273235.
2011
Predictors of early versus late timing of pulmonary embolus after traumatic injury.
American journal of surgery.
201(2):209-15
[DOI] 10.1016/j.amjsurg.2009.12.005.
[PMID] 20385370.
2009
Boerhaave syndrome presenting as massive hemothorax.
Southern medical journal.
102(2):202-3
[DOI] 10.1097/SMJ.0b013e318186be00.
[PMID] 19139705.
2006
High-frequency percussive ventilation improves oxygenation in trauma patients with acute respiratory distress syndrome: a retrospective review.
American journal of surgery.
192(2):191-5
[PMID] 16860628.
2005
DC-SIGN can modulate IL-2 production from PMA and anti-CD3 stimulated primary human CD4 T cells
.
17(6):769-778
2004
The ultrasound screen for penetrating truncal trauma.
The American surgeon.
70(4):316-21
[PMID] 15098784.
2003
Detection of intra-abdominal injury using diagnostic peritoneal lavage after shotgun wound to the abdomen.
The Journal of trauma.
54(2):329-31
[PMID] 12579060.
2003
Detection of intra-abdominal injury using diagnostic peritoneal lavage following shotgun wound to the abdomen
.
54(2):329-331
2002
A prospective evaluation of the sensitivity of physical examination in chest trauma
.
53:1135-1138
2002
Prospective evaluation of the sensitivity of physical examination in chest trauma.
The Journal of trauma.
53(6):1135-8
[PMID] 12478040.
Grants
Jul 2019
– Sep 2020
Linking Investigations in Trauma and Emergency Services (LITES) Task Order 2: Shock, Whole blood and Assessment of TBI (SWAT)
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH MED CNTR
via US ARMY MED RES AND DEVELOPMENT COMMAND
Jul 2018
– Jul 2023
ATB-203: Phase 2 randomized, double-blind, placebo-controlled, parallel-group study to evaluate the safety and efficacy of Reltecimod as compared to placebo in addition to standard of care in patients with sepsis-associated acute kidney injury (SA-AKI)
Role: Principal Investigator
Funding: ATOX BIO LTD
Jun 2018
– May 2020
PICS: A New Horizon for Surgical Critical Care
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Sep 2017
– Sep 2020
The Pathogenesis of Post-Traumatic Pulmonary Embolism: A Prospective Multi-Center INvestigation by the CLOTT Study Group (CLOTT)
Role: Co-Project Director/Principal Investigator
Funding: COALITION FOR NATL TRAUMA RES
via US ARMY MED RES AND DEVELOPMENT COMMAND
Sep 2017
– May 2020
The acute development and persistence of frailty, comorbidity and disability in critically ill elderly patients after severe traumatic injury: induced frailty
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jun 2017
– May 2018
PICS: A New Horizon for Surgical Critical Care
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2017
– Jun 2021
OoR CTSI Institutional Matching Support
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Jan 2017
– Jan 2020
Randomized, Double-Blind, Parallel Group Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BMS-936558 (nivolumab) in Participants with Severe Sepsis or Septic Shock.
Role: Principal Investigator
Funding: BRISTOL MYERS SQUIBB CO
Jun 2016
– May 2017
PICS: A New Horizon for Surgical Critical Care
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Apr 2016
– Mar 2017
Claude D Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Dec 2015
– Dec 2018
PHASE 1B/2A, RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED,MULTICENTER STUDY TO EVALUATE THE SAFETY, TOLERABILITY….
Role: Principal Investigator
Funding: BRISTOL MYERS SQUIBB CO
Jul 2015
– Jun 2018
The Acute Development and Persistence of Frailty. Comorbidity and Disability in Critically ILL Patients After.
Role: Principal Investigator
Funding: FL CLINICAL PRACTICE ASSO
Jun 2015
– May 2016
PICS: A New Horizon for Surgical Critical Care
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Apr 2015
– Mar 2016
Claude D. Pepper Older Americans Independence Center
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Mar 2015
– Dec 2019
Phase III, randomized, double-blind, placebo-controlled, parallel-group, study of AB103 as compared to placebo in patients with necrotizing soft tissue infections (NSTI)
Role: Principal Investigator
Funding: ATOX BIO LTD
via BIOMEDICAL ADVANCED RES & DEVLPMT AUTHOR
Contact Details
Phones:
- Business:
- (352) 273-5670
Emails:
- Business:
- sbrakenr@ufl.edu
Addresses:
- Business Mailing:
-
325 9TH AVE
SEATTLE WA 98104 - Business Street:
-
325 9th Ave
Seattle WA 98006