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Microbiology and Cell Science

Astrocytes are essential cells of the mammalian central nervous system (CNS), with key roles in development, homeostasis, and disease. Lee and colleagues recently showed that astrocytes can develop...

Brain border-associated macrophages: common denominators in infection, aging, and Alzheimer’s disease?

April 16, 2024

Mammalian brain border-associated macrophages (BAMs) are strategically positioned to support vital properties and processes: for example, the composition of the brain’s perivascular extracellular...

Complement(ing) long-COVID thromboinflammation and pathogenesis

April 17, 2024

The persistence or recurrence of symptoms after acute SARS-CoV-2 infection, termed ‘long COVID’, presents a formidable challenge to global healthcare systems. Recent research by Cervia-Hasler and...

Lymphoid tissue on the mind

April 17, 2024

To surveil an organ for pathogens, lymphoid structures need to sample antigens locally. The full set of lymphoid structures involved in surveilling for brain-tropic pathogens has not been defined....

Microglia pack a toolbox for life

April 13, 2024

After decades of being overlooked, a recent wave of studies have explored the roles of microglia in brain health and disease. Microglia perform important physiological functions to set up and maintain...

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