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Trends in Immunology

Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?

September 18, 2023

Humans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different...

Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons

September 11, 2023

Klebsiella pneumoniae is among the most common antibiotic-resistant pathogens causing nosocomial infections. Additionally, it is a leading cause of neonatal sepsis and childhood mortality across the...

The diversity of cGLR receptors: shedding new light on innate immunity

September 15, 2023

The characterization of a new group of innate pattern recognition receptors detected in >500 species across the tree of life by Li et al. reveals surprising commonalities and peculiarities shared...

cGAS-like receptors: back to the future

September 15, 2023

Recent studies have characterized ancient forms of cyclic GMP-AMP (cGAMP) synthase (cGAS)-like receptors (cGLRs) in bacterial and Drosophila immunity. Using bioinformatics and biochemical screening,...

pH sensing at the intersection of tissue homeostasis and inflammation

September 13, 2023

pH is tightly maintained at cellular, tissue, and systemic levels, and altered pH – particularly in the acidic range – is associated with infection, injury, solid tumors, and physiological and...

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