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Trends in Immunology

Beyond antiviral: role of IFN-I in brain development

April 20, 2024

Interferons and central nervous system resident macrophages, microglia, are well-known for their respective roles in antiviral defense and phagocytosis. Using a classic experimental paradigm for...

Bridging anatomical gaps between brain and immune system

April 23, 2024

It is increasingly clear that the central nervous system (CNS) relies significantly on both adaptive and innate immune cells for its repair and lifelong maintenance. These interactions hold profound...

Embryonic microglia maintain the brain's cortical fault lines

April 24, 2024

Lawrence et al. report that fetal cortical boundaries are susceptible to morphogenetic stress that regulates a microglia state resembling postnatal, axon-tract associated microglia (ATM). This state...

Microglia as integrators of brain-associated molecular patterns

April 23, 2024

Microglia are brain-resident macrophages that play key roles in brain development and experience dependent plasticity. In this review we discuss recent findings regarding the molecular mechanisms...

Sensory neuronal control of skin barrier immunity

April 22, 2024

Peripheral sensory neurons recognize diverse noxious stimuli, including microbial products and allergens traditionally thought to be targets of the mammalian immune system. Activation of sensory...

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